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M2-PK, as measured in feces, is a potential tumor marker for colorectal cancer.When measured in feces with a cutoff value of 4 U/ml, its sensitivity has been estimated to be 85% (with a 95% confidence interval of 65 to 96%) for colon cancer and 56% (confidence interval 41–74%) for rectal cancer. [1]
An elevated concentration of M2-PK in the stool should always be clarified by undergoing colonoscopy. The gold standard of early detection of colon polyp/cancer is the invasive colonoscopy, but with high expense about $557, while tumor marker M2-PK Test expense only about $15-$25. The invasive colonoscopy makes acceptance of it low among ...
The quantification of Tumor M2-PK in plasma and stool is a tool for early detection of tumors and follow-up studies during therapy. The dimerization of PKM2 in tumor cells is induced by direct interaction of PKM2 with different oncoproteins (pp60v-src, HPV-16 E7, and A-Raf).
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The M2 machine gun or Browning .50 caliber machine gun (informally, "Ma Deuce") [13] [14] is a heavy machine gun that was designed near the end of World War I by John Browning. While similar to Browning's M1919 Browning machine gun , which was chambered for the .30-06 cartridge, the M2 uses Browning's larger and more powerful .50 BMG (12.7 mm ...
The Hyde-Inland M2 was a United States submachine gun design submitted for trials at Aberdeen Proving Ground in February 1941. Work was undertaken by General Motors Inland Manufacturing Division to develop workable prototypes of George Hyde 's design patented in 1935 ( U.S. patent 2049776A ).
The M1897 guns used the same 75×350 mm R ammunition as the 75 mm gun M2/M3/M6 tank guns of the M3 Lee, M4 Sherman, M24 Chaffee, and 'gunship' version of the North American B-25 Mitchell bomber. The M2 was a L/31 gun, the M1897 was L/36, and the M3 was L/40.
PK machine guns that feature a Warsaw Pact side-rail bracket on the left side of the receiver can mount various aiming optics. The standard Russian side rail mounted optical sight was the 4×26 1P29 Universal sight for small arms, an aiming optic similar to the British SUIT and SUSAT and Canadian C79 optical sights. When mounted, the 1P29 sight ...