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Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. Note: Dosages are not necessarily equivalent.
Trough estradiol levels and MADRS Tooltip Montgomery–Åsberg Depression Rating Scale scores with 1 mg sublingual micronized estradiol 3 to 8 times per day (3 to 8 mg/day total; mean 4.8 mg/day total) in women with postpartum depression. [8] Blood was drawn specifically in the mornings before the first dose of sublingual estradiol for the day. [8]
For women who have not undergone a hysterectomy, it is often suggested that they take progestogen in addition to an estrogen patch in order to protect the endometrium of the uterus. [ 1 ] [ 2 ] Transdermal estrogens are not recommended for all women; there are important precautions and side effects that should be considered before use.
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[63] [64] A dosage of oral CEEs of 2.5 mg three times daily (7.5 mg/day total) has been found to suppress total testosterone levels in men to an equivalent extent as 3 mg/day oral diethylstilbestrol, which is the minimum dosage of diethylstilbestrol required to consistently suppress total testosterone levels into the castrate range (<50 ng/dL).
In combination with progestins for endometriosis in women. Although initially used alone, progestins were added in the 1960s and 1970s. [11] In addition, the estrogen diethylstilbestrol is an example of medical reversal as it increases the risk of endometriosis in the treated women and in their female children. [12] [13] Osteopenia and ...
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Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of reproduction. [1] [6] [7] It typically occurs between the ages of 45 and 55, although the exact timing can vary. [8]