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Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, COVID‑19, and systemic sclerosis-associated interstitial lung disease ...
Certolizumab pegol, sold under the brand name Cimzia, is a biopharmaceutical medication for the treatment of Crohn's disease, [4] [5] rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.
Muromonab-CD3 (brand name Orthoclone OKT3, marketed by Janssen-Cilag) is an immunosuppressant medication given to reduce acute rejection in people with organ transplants. [1] [2] It is a monoclonal antibody targeted at the CD3 receptor, [3] a membrane protein on the surface of T cells.
Guselkumab was developed by Janssen Pharmaceuticals. [16] In November 2016, Janssen submitted a Biologics License Application (BLA) to the FDA seeking approval of guselkumab.
Alefacept is a genetically engineered immunosuppressive drug.It was sold under the brand name Amevive in Canada, the United States, Israel, Switzerland and Australia.In 2011, the manufacturers made a decision to cease promotion, manufacturing, distribution and sales of Amevive during a supply disruption.
Toralizumab (IDEC 131) was a humanized monoclonal antibody and an immunosuppressive drug.Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn's disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation ...
Tofacitinib, sold under the brand Xeljanz among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polyarticular course juvenile idiopathic arthritis, and ulcerative colitis.
Daclizumab was used to treat adults with relapsing forms of multiple sclerosis. [6] It is administered subcutaneously. [7]In clinical trials, decreases of 45% in annualized relapse rate have been reported, as well as a 41% reduction in the proportion of patients who relapsed, and a 54% reduction in the number of new lesions. [7]
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