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Osteoclasts dissolve and break down old or damaged bone cells. They make space for osteoblasts to create new bone tissue in areas that are growing or need repair. If osteoblasts are builders, osteoclasts are your bones’ demolition crew.
Light micrograph of an osteoclast displaying typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy" cytosol. An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue.
Osteoclasts are specialized bone matrix cells that possess the ability to erode bone, a process called resorption, during bone growth and remodeling. They are large, motile, multinucleated cells derived from the fusion of cells of the macrophage-monocyte cell line.
Functioning as vital cells in the bone matrix that maintains adequate bone mineral density through stimulating bone turnover and maintaining plasma calcium levels, osteoclasts are multinucleate cells that arise from hematopoietic stem cells.
Because osteoclasts are culprits in many diseases of systemic and local bone loss, their activity is essential for the process of bone remodeling that replaces effete, brittle bone with new. The osteoclast, which is the sole bone-resorbing cell, is a unique polykaryon whose activity, in the context of the osteoblast, dictates skeletal mass.
The osteoclasts are the mediators of the continuous destruction of bone. Osteoclasts occupy small depressions on the bone’s surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts’ enzymes.
Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in ...
Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb large quantities of bone. Therefore, they are frequently the target of therapeutic interventions to ameliorate bone loss.
Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders.
Osteoclasts are the principal cells that efficiently resorb bone. Numerous studies have attempted to reveal the molecular pathways leading to the differentiation and activation of...