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Phi Sigma Pi National Honor Fraternity (ΦΣΠ) is a gender-inclusive/mixed-sex national honor fraternity based in the United States. [1] The fraternity is a 501(c)(3) not-for-profit organization incorporated in the state of Pennsylvania to foster scholarship, leadership, and fellowship.
The Phi Sigma honor society was founded on March 17, 1915, at Ohio State University to honor excellence in biological research. [ 1 ] [ 2 ] In 1928 its constitution was so altered that the society "should now be considered as a working guild", with a focus on ongoing research.
Sotorasib, sold under the brand names Lumakras and Lumykras, is an anti-cancer medication used to treat non-small-cell lung cancer. [4] [5] It targets a specific mutation, G12C, in the protein K-Ras encoded by gene KRAS which is responsible for various forms of cancer. [7] [8] Sotorasib is an inhibitor of the RAS GTPase family. [4]
The most common side effects include decreased hemoglobin, anemia, fatigue, increased creatinine, headache, dizziness, increased glucose, and nausea. [ 10 ] Belzutifan was approved for medical use in the United States in August 2021, [ 10 ] [ 18 ] in the United Kingdom in May 2022, [ 8 ] and in the European Union in February 2025.
Repotrectinib, sold under the brand name Augtyro, is an anti-cancer medication used for the treatment of non-small cell lung cancer. [ 1 ] [ 4 ] It is taken by mouth . [ 1 ] Repotrectinib is an inhibitor of proto-oncogene tyrosine-protein kinase ROS1 ( ROS1 ) and of the tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC.
Tucatinib is a kinase inhibitor indicated in combination with trastuzumab and capecitabine for the treatment of adults with advanced unresectable or metastatic HER2-positive breast cancer, including those with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting.
The most common side effects include fatigue (tiredness), hypertension (high blood pressure), diarrhea, decreased appetite, nausea, dysphonia (voice changes), hypothyroidism, cough, and stomatitis. [4] [3] [5] Tivozanib was approved for medical use in the European Union in August 2017, [4] and in the United States in March 2021. [3] [5]
Phi Sigma Sigma (ΦΣΣ), colloquially known as Phi Sig, was the first collegiate nonsectarian sorority to allow membership of women of all faiths and backgrounds. [1]The sorority was founded on November 26, 1913, and lists 60,000 initiated members, 115 collegiate chapters, and more than 100 alumnae chapters, clubs, and associations in the United States and Canada.