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The side effects of bicalutamide, a nonsteroidal antiandrogen (NSAA), including its frequent and rare side effects, have been well-studied and characterized. The most common side effects of bicalutamide monotherapy in men include breast tenderness , breast growth , feminization , demasculinization , and hot flashes .
Common side effects of bicalutamide in men include breast growth, breast tenderness, and hot flashes. [10] Other side effects in men include feminization and sexual dysfunction. [22] [23] Some side effects like breast changes and feminization are minimal when combined with castration. [24] While the medication appears to produce few side ...
Another large study reported a rate of impotence of only 9.3% with bicalutamide relative to 6.5% for standard care (the controls), a rate of decreased libido of only 3.6% with bicalutamide relative to 1.2% for standard care, and a rate of 9.2% with bicalutamide for hot flashes relative to 5.4% for standard care. [125]
A dosage of bicalutamide of 2 mg/kg (or about 40 to 60 mg in boys that are 20 to 30 kg or 45 to 65 lbs) once daily is recommended for use in male peripheral precocious puberty. [149] Bicalutamide is used to block the actions of androgens in the condition, while the aromatase inhibitor is used to decrease levels of estrogens. [148]
Major side effects of bicalutamide [1] [2] [3] [4] [5] [6] [7]; Frequency Class of effect Effect Very common (≥10%) Reproductive system and breast disorders ...
Salk Institute researchers have identified a key protein that may help users of GLP-1 drugs such as Ozempic and Wegovy maintain muscle mass while losing weight.
“When you didn’t get enough sleep or didn’t get good quality sleep, the likelihood that an extra 5 to 10 minutes of sleep could make a meaningful impact is pretty low,” Dr. Joseph ...
[1] [2] However, the absolute bioavailability of bicalutamide has been found to be high in animals at low doses (109% in mice at 10 mg/kg; 72% in rats at 1 mg/kg; 100% in dogs at 0.1 mg/kg), but diminishes with increasing doses such that the bioavailability of bicalutamide is low at high doses (10% in rats at 250 mg/kg; 31% in dogs at 100 mg/kg).
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