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Iron-deficiency anemia is anemia caused by a lack of iron. [3] Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. [3] When onset is slow, symptoms are often vague such as feeling tired, weak, short of breath, or having decreased ability to exercise. [1]
Anemia affects 27% of the world's population with iron-deficiency anemia accounting for more than 60% of it. [116] A moderate degree of iron-deficiency anemia affected approximately 610 million people worldwide or 8.8% of the population. [14] It is somewhat more common in females (9.9%) than males (7.8%). [14]
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Anemia is a deficiency in the size or number of red blood cells or in the amount of hemoglobin they contain. [1] This deficiency limits the exchange of O 2 and CO 2 between the blood and the tissue cells. [1] Globally, young children, women, and older adults are at the highest risk of developing anemia. [1]
It most usually occurs in postmenopausal women. Vitamin B12 deficiency anemia: E53.8: 13905: Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red blood cells. [7] Vitamin B12 deficiency anemia due to intrinsic factor deficiency: D51.0
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The normal range for hemoglobin is 13.8 to 17.2 grams per deciliter (g/dL) for men and 12.1 to 15.1 g/dL for women. [6] Low hemoglobin indicates anemia but the individual will be normal for LID. [5] Normal serum iron is between 60 and 170 micrograms per dL (μg/dL). [7] Normal total iron-binding capacity for both sexes is 240 to 450 μg/dL. [6]