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Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABA A receptor [ 3 ] and displays sedative-hypnotic , depressant and hallucinogenic [ citation needed ] psychoactivity .
Ibotenic acid or (S)-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid, also referred to as ibotenate, is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere.
As with other Amanita muscaria, the inzengae variety contains ibotenic acid, and muscimol, two psychoactive constituents which can cause effects such as hallucinations, synaesthesia, euphoria, dysphoria and retrograde amnesia. The effects of muscimol and ibotenic acid most closely resemble that of any GABAergic compound, but with a dissociative ...
Trace concentrations of muscarine are also found in Amanita muscaria, though the pharmacologically more relevant compound from this mushroom is the Z-drug-like alkaloid muscimol. A. muscaria fruitbodies contain a variable dose of muscarine, usually around 0.0003% fresh weight. This is very low and toxicity symptoms occur very rarely.
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The effects of muscimol and ibotenic acid most closely resemble that of a Z drug, like Ambien at high doses, and not a classical psychedelic, e.g. psilocybin. A. pantherina is used as an entheogen much less often than its much more distinguishable relative A. muscaria, largely due to being less recognizable and far more potent.
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Author recommends 8.5 mg of muscimol, which is stated to be present in as little as 1 g of dried mushroom." etc. This adds clarity between the subject chemical dosage and the carrier food/fungus amount to be injested, and given that the subject of the article is the chemical itself, would provide better insight into dosing, whether the fungus ...
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