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Cilostazol was approved for medical use in the United States in 1999. [2] It is available as a generic medication. [3] In 2019, it was the 347th most commonly prescribed medication in the United States, with more than 800 thousand prescriptions. [4]
An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation [1] and inhibit thrombus formation.
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
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Drugs or medicines may be withdrawn from commercial markets because of risks to patients, but also because of commercial reasons (e.g. lack of demand and relatively high production costs).
Like other methylated xanthine derivatives, pentoxifylline is a competitive nonselective phosphodiesterase inhibitor [20] which raises intracellular cAMP, activates PKA, inhibits TNF [21] [22] and leukotriene [23] synthesis, and reduces inflammation and innate immunity. [23]
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