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Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
When synthetic cannabinoids are used recreationally, they present significant health dangers to users. [100] In the period of 2012 through 2014, over 10,000 contacts to poison control centers in the United States were related to use of synthetic cannabinoids. [100] Medications containing natural or synthetic cannabinoids or cannabinoid analogs:
Cannabinoids and their K i values [a] Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x) JWH ...
Nelson claims that relative to marijuana, products containing synthetic cannabinoids "are really quite different, and the effects are much more unpredictable. It's dangerous". [47] Since the term synthetic does not apply to the plant, but rather to the cannabinoid that the plant contains , the term synthetic cannabinoid is more appropriate. [48]
Pages in category "Cannabinoids" The following 200 pages are in this category, out of approximately 301 total. This list may not reflect recent changes.
The cannabis plant contains more than 100 cannabinoids, including THC and CBD, and hundreds of non-cannabinoid chemicals. Scientists are just beginning to understand the effect these compounds ...
The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ 9-tetrahydrocannabinol (THC), but only THC is psychoactive. [55] Since the early 1970s, Cannabis plants have been categorized by their chemical phenotype or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD. [56]
Cannabinoids and their affinities, selectivities and structures Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity CLogP Structure Description AM-087: Dibenzopyran: 0.43: 6.47: An analgesic CB 1 agonist derived from Δ 8-THC substituted with a side chain on the 3-position, roughly 100 times as potent as THC. AM-251: Pyrazole derivative: 7 ...