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Elevated troponin levels are prognostically important in many of the conditions in which they are used for diagnosis. [36] In a community-based cohort study indicating the importance of silent cardiac damage, troponin I has been shown to predict mortality and first coronary heart disease event in men free from cardiovascular disease at baseline ...
Test Sensitivity and specificity Approximate peak Description Troponin test: The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is composed of 3 proteins- Troponin C, Cardic troponin I, and Cardiac troponin T. Troponin I especially has a high affinity for myocardial injury.
In statistics, an effect size is a value measuring the strength of the relationship between two variables in a population, or a sample-based estimate of that quantity. It can refer to the value of a statistic calculated from a sample of data, the value of one parameter for a hypothetical population, or to the equation that operationalizes how statistics or parameters lead to the effect size ...
Troponin I is a biomarker that responds to treatment interventions. Reductions in troponin I levels proved to reduce the risk of future CVD. [23] [24] [25] High sensitive troponin I used as a screening tool to assess a person's cardiovascular risk and has the potential to reduce the growing cost burden of the healthcare system. [26]
7134 21924 Ensembl ENSG00000114854 ENSMUSG00000091898 UniProt P63316 P19123 RefSeq (mRNA) NM_003280 NM_009393 RefSeq (protein) NP_003271 NP_033419 Location (UCSC) Chr 3: 52.45 – 52.45 Mb Chr 14: 30.93 – 30.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated ...
Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene. [5] [6]The TNNI2 gene is located at 11p15.5 in the human chromosomal genome, encoding the fast twitch skeletal muscle troponin I (fsTnI). fsTnI is a 21.3 kDa protein consisting of 182 amino acids including the first methionine with an isoelectric point (pI) of 8.74.
[5] [6] [7] It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex. Gene TNNI1 , troponin I type 1 (skeletal muscle, slow), also known as TNN1 and SSTNI , is located at 1q31.3 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin I (ssTnI), the inhibitory subunit of ...
In statistics, the Sobel test is a method of testing the significance of a mediation effect. The test is based on the work of Michael E. Sobel, [1] [2] and is an application of the delta method. In mediation, the relationship between the independent variable and the dependent variable is hypothesized to be an indirect effect that exists due to ...