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Focal neurological deficits may be caused by a variety of medical conditions such as head trauma, [1] tumors or stroke; or by various diseases such as meningitis or encephalitis or as a side effect of certain medications such as those used in anesthesia. [2] Neurological soft signs are a group of non-focal neurologic signs. [3]
A focal aware temporal lobe seizure occurs if a person remains aware of what occurs during the entire seizure; awareness may be retained even if impaired responsiveness occurs during the seizure. [10] A focal impaired awareness temporal lobe seizure occurs if a person becomes unaware during any part of the seizure. [10]
A focal impaired awareness seizure affects a larger part of the hemisphere and the person may lose consciousness. If a focal seizure spreads from one hemisphere to the other side of the brain, this will give rise to a focal to bilateral seizure. [5] [6] The person will become unconscious and may experience a tonic–clonic seizure.
Focal means that it is limited to a focal zone in any lobe. [2] Focal cortical dysplasia is a common cause of intractable epilepsy in children and is a frequent cause of epilepsy in adults. There are three types of FCD with subtypes, including type 1a, 1b, 1c, 2a, 2b, 3a, 3b, 3c, and 3d, each with distinct histopathological features.
However, the "reason for the close relationship of TEA with sleep is unclear. It may be that the transition from sleep to waking acts as a trigger to a seizure focus in the medial temporal lobe. Alternatively, amnesia upon waking may reflect persistent post-ictal dysfunction of medial temporal lobe structures following a seizure during sleep." [2]
Hippocampal sclerosis (HS) or mesial temporal sclerosis (MTS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus. [1] Neuroimaging tests such as magnetic resonance imaging (MRI) and positron emission tomography (PET) may identify individuals with hippocampal sclerosis. [ 2 ]
Even a mild incident can have long-term effects or cause symptoms to appear years later. [5] Studies show there is a correlation between brain lesion and language, speech, and category-specific disorders. Wernicke's aphasia is associated with anomia, unknowingly making up words , and problems with comprehension.
Frontotemporal dementia (FTD) is an early onset disorder that mostly occurs between the ages of 45 and 65, [13] but can begin earlier, and in 20–25% of cases onset is later.