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Statins appear to be effective at preventing cardiovascular disease and death in older adults, according to new research. Most clinical trials evaluating statins have not included people 75 and ...
In people over the age of 70, statins decrease the risk of cardiovascular disease but only in those with a history of heavy cholesterol blockage in their arteries. [24] Most evidence suggests that statins are also effective in preventing heart disease in those with high cholesterol but no history of heart disease.
Chen explained statins work by decreasing the amount of cholesterol made by the liver. “By doing that, it decreases your total circulating blood cholesterol levels ,” he said. Statins do not ...
New research finds that many people currently taking statins to lower cholesterol may not actually need this medication. An analysis, published in JAMA Internal Medicine , investigates how statin ...
Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body’s natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at lowering LDL cholesterol if taken in the evening ...
Statins are a competitive antagonists of HMG CoA, as they directly compete with the endogenous substrate for the active site cavity of HMGR. Statins are also noncompetitive with the cosubstrate NADPH (nicotinamide adenine dinucleotide phosphate). [5] By blocking the HMGR enzyme they inhibit the synthesis of cholesterol via the mevalonate pathway.
Overall, our findings suggest that more people over 70 years of age should be considered for statin treatment.” — Borislava Mihaylova, DPhil “Cardiovascular disease remains a leading cause ...
These antibodies are known to also occur in people who do not take statin medications. [3] Conversely, these antibodies are absent in people who take statin medications but do not have myopathy. Thus, the presence of anti-HMG CoA reductase antibodies in someone who uses a statin and has myopathy strongly supports the diagnosis. [3]
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