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Tizanidine, sold under the brand name Zanaflex among others, is an alpha-2 (α 2) adrenergic receptor agonist, [2] similar to clonidine, that is used to treat muscle spasticity due to spinal cord injury, multiple sclerosis, and spastic cerebral palsy. [3] Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5]
Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. [5] It is not useful in cerebral palsy . [ 5 ]
Tizanidine is perhaps the most thoroughly studied clonidine analog, and is an agonist at α 2-adrenergic receptors, but reduces spasticity at doses that result in significantly less hypotension than clonidine. [26]
Tizanidine was found to decrease the average frequency of headaches per week, the headache intensity, and the mean headache duration. [15] Through studies, Fluoxetine resulted in better mood ratings and "significant increases in headache-free days". [16]
It’s more widely available than FDA-approved tirzepatide, which is currently experiencing shortages, and it’s cheaper too. Compounded tirzepatide can also be made to suit the specific needs of ...
The researchers found that people who walk 5,000 or more steps per day generally felt less depressed than those who walked fewer than 5,000. What’s more, people who walk 7,000 or more steps per ...
While we don’t have much research on 10% and 15% minoxidil, the stronger stuff doesn’t appear to be better. In fact, the 5% solution may be the most effective of all.
Moreover, it suggests that cyclobenzaprine is virtually a controlled substance—such a statement doesn't exist with the other common (non-controlled) muscle relaxants tizanidine, metaxalone and chlorzoxazone. I'm not aware of any jurisdiction or guideline where cyclobenzaprine is a controlled substance.
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