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PCBs may play a role in the development of cancers of the immune system because some tests of laboratory animals subjected to very high doses of PCBs have shown effects on the animals' immune system, and some studies of human populations have reported an association between environmental levels of PCBs and immune response.
Bioremediation of PCBs is the use of microorganisms to degrade PCBs from contaminated sites, relying on multiple microorganisms' co-metabolism. Anaerobic microorganisms dechlorinate PCBs first, and other microorganisms that are capable of doing BH pathway can break down the dechlorinated PCBs to usable intermediates like acyl-CoA or carbon ...
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
Polychlorinated biphenyls (PCBs), derived from biphenyl, of which 12 are "dioxin-like". Under certain conditions PCBs may form dibenzofurans through partial oxidation. Polybrominated analogs of the above classes may have similar effects. "Dioxin" can also refer to 1,4-dioxin or p-dioxin, the basic chemical unit of the more complex dioxins. This ...
Test results conducted in the fall showed the presence of PCBs, or polychlorinated biphenyls — toxic, man-made chemicals that were banned from being produced in the United States in 1979.
PCBs are toxic to fish at high doses, and associated with spawning failure at low doses. Human exposure occurs through food, and is associated with reproductive failure and immune suppression. Immediate effects of PCB exposure include pigmentation of nails and mucous membranes and swelling of the eyelids, along with fatigue, nausea, and vomiting.
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PCB contamination in humans may come from drinking the contaminated water, absorption through the skin, eating contaminated aquatic life, and/or inhaling volatilized PCBs. PCB contamination is especially dangerous for pregnant and nursing women. The contamination can reach the fetus and potentially cause birth defects.
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