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The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a novel safety pharmacology paradigm intending to provide a more accurate assessment of cardiac safety testing for potential proarrhythmic events in human. [11] This initiative is driven by a steering team including partners from US FDA, HESI, CSRC, SPS, EMA, Health Canada, Japan NIHS ...
Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood.Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed. [1]
In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...
Both pharmacology and toxicology are scientific disciplines that focus on understanding the properties and actions of chemicals. [23] However, pharmacology emphasizes the therapeutic effects of chemicals, usually drugs or compounds that could become drugs, whereas toxicology is the study of chemical's adverse effects and risk assessment. [23]
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration. [1]
The Journal of Pharmacy and Pharmacology is a monthly peer-reviewed scientific journal covering all aspects of pharmacy and pharmacology. It is published by Wiley-Blackwell on behalf of the Royal Pharmaceutical Society. It is an official journal of the British Pharmaceutical Conference. It was established in 1870 and acquired its current title ...
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