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Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names Sebivo (European Union) and Tyzeka (United States). Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance.
Achieving this goal would require the development of therapeutic treatments to cure chronic hepatitis B, as well as preventing its transmission and using vaccines to prevent new infections. [15] [16] [17] An estimated 296 million people, or 3.8% of the global population, had chronic hepatitis B infections as of 2019.
Adefovir dipivoxil. Adefovir works by blocking reverse transcriptase, an enzyme crucial for the HBV to reproduce in the body.It is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease.
Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV/AIDS. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long-term use of lamivudine leads to emergence of a resistant hepatitis B virus (YMDD) mutant. [11]
For the medical community, the Hepatitis B Foundation organizes the International HBV Scientific Meeting annually for scientists discuss to new discoveries in hepatitis B research. [12] The organization is also actively involved in policy-making, helping ensure hepatitis B is a health priority at the local and federal level. [13] [14] [15]
The DAA drugs against hepatitis C are taken orally, as tablets, for 8 to 12 weeks. [56] The treatment depends on the type or types of hepatitis C virus that are causing the infection. [57] Both during and at the end of treatment, blood tests are used to monitor the effectiveness of the treatment and subsequent cure. [56]
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