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Esomeprazole's successful predecessor, omeprazole, is a mixture of two mirror-imaged molecules (esomeprazole which is the S-enantiomer, and R-omeprazole); critics said the company was trying to "evergreen" its omeprazole patent by patenting the pure esomeprazole and aggressively marketing to doctors that it is more effective than the mixture. [50]
Naproxen/esomeprazole, sold under the brand name Vimovo, is a pain reliever medication in the form of a tablet for oral consumption, containing naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and a delayed release formulation of esomeprazole, a stomach acid–reducing proton-pump inhibitor (PPI). [2] [3] It is produced by AstraZeneca. [4]
Esomeprazole is the (S)-(−)-enantiomer of omeprazole and provides higher bioavailability and improved efficacy, in terms of stomach acid control, over the (R)-(+)-enantiomer of omeprazole. In theory, by using pure esomeprazole the effects on the proton pump will be equal in all patients, eliminating the "poor metabolizer effect" of the ...
AstraZeneca also developed esomeprazole (Nexium) which is a eutomer, purely the (S)-enantiomer, rather than a racemate like omeprazole. [medical citation needed] Omeprazole undergoes a chiral shift in vivo which converts the inactive (R)-enantiomer to the active (S)-enantiomer, doubling the concentration of the active form. [59]
These medications are used in the treatment of many conditions, such as: Dyspepsia [9] [10]; Peptic ulcer disease including after endoscopic treatment for bleeding [11]; As part of Helicobacter pylori eradication therapy [12]
"Esomeprazole is the (S)-(−)-enantiomer (or less specifically the S-isomer) of omeprazole." Has the following footnote: "The name thus is an onomatopoeia, as it can also be read as Es + omeprazole" It doesn't really make any sense. Neither omeprazole nor esomeprazole are describing a sound, regardless of the latter's prefix.
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Српски / srpski; Srpskohrvatski / српскохрватски ... Esomeprazole; Omeprazole This page was last edited on 6 May 2021, at 01:32 ...
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