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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Sevoflurane has an excellent safety record, [13] but is under review for potential hepatotoxicity, and may accelerate Alzheimer's. [16] There were rare reports involving adults with symptoms similar to halothane hepatotoxicity. [13] Sevoflurane is the preferred agent for mask induction due to its lesser irritation to mucous membranes.
Hepatotoxicity. [3] Dimazole (Diamthazole) 1972 France, US Neuropsychiatric reaction. [3] Dimethylamylamine (DMAA) 1983 US Voluntarily withdrawn from market by Lily. [17]: 12 Reintroduced as a dietary supplement in 2006; [17]: 13 in 2013 the FDA started work to ban it due to cardiovascular problems [18] Dinoprostone: 1990 UK
Users of Alli and Xenical, beware -- the diet drugs may cause liver failure, according to the U.S. Food and Drug Administration. In a statement released on May 26, the government agency said ...
Of these, amoxicillin-clavulanate is the most common cause of drug-induced liver injury, and paracetamol toxicity the most common cause of acute liver failure in the United States and Europe. [36] Herbal remedies and dietary supplements are another important cause of hepatitis; these are the most common causes of drug-induced hepatitis in Korea ...
Paracetamol poisoning is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand. [41] [42] [43] Paracetamol was first made in 1878 by Harmon Northrop Morse or possibly in 1852 by Charles Frédéric Gerhardt.
"Carfentanil can also resemble cocaine and heroin, so it blends right in with the other drugs," he warned. "Even a tiny amount can increase the potency of a drug mixture, leading to a stronger and ...
Tolcapone has demonstrated significant liver toxicity (hepatotoxicity) [13] that limits the drug's utility. Entacapone is an alternative, largely since it has a more favorable toxicity profile. The hepatotoxicity can be related to elevated levels of transaminases , but studies have shown that minimal risk exists for those without preexisting ...