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The rifamycin group includes the classic rifamycin drugs as well as the rifamycin derivatives rifampicin (or rifampin), rifabutin, rifapentine, rifalazil and rifaximin. Rifamycin, sold under the trade name Aemcolo, is approved in the United States for treatment of travelers' diarrhea in some circumstances. [1] [2] [3]
Rifampicin is also known as rifaldazine, [63] [64] rofact, and rifampin in the United States, also as rifamycin SV. [ 65 ] Its chemical name is 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)-naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate.
It produces the rifamycin antibiotics (e.g., rifamycin SV), which are used to treat mycobacterial diseases such as tuberculosis and leprosy. [2] The type strain of Amycolatopsis rifamycinica (DSM 46095) has been reclassified several times. When it was first isolated from a French soil sample in 1957, it was identified as Streptomyces ...
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Rifaximin, sold under the brand name Xifaxan among others, is a non-absorbable, broad-spectrum antibiotic mainly used to treat travelers' diarrhea.It is based on the rifamycin antibiotics family.
It contains ethambutol, isoniazid, and rifampicin. [1] It is used either along or with other anti-tuberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1] Use may not be suitable in children. [1] It is on the World Health Organization's List of Essential Medicines. [2]
Rifapentine, sold under the brand name Priftin, is an antibiotic used in the treatment of tuberculosis. [2] In active tuberculosis it is used together with other antituberculosis medications. [2]
It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide. [1] It is used either by itself or along with other antituberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness ...