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However, further research is needed in the form of randomised trials to demonstrate its role in the treatment of benzodiazepine withdrawal. [ 89 ] [ needs update ] Flumazenil stimulates the up-regulation and reverses the uncoupling of benzodiazepine receptors to the GABA A receptor , thereby reversing tolerance and reducing withdrawal symptoms ...
Long-term use of benzodiazepines can induce perceptual disturbances and depersonalization in some people, even in those taking a stable daily dosage, and it can also become a protracted withdrawal feature of the benzodiazepine withdrawal syndrome. [55] In addition, chronic use of benzodiazepines is a risk factor for blepharospasm. [56]
With long-term use and during withdrawal of benzodiazepines, treatment-emergent depression and [7] emotional blunting may emerge and sometimes also suicidal ideation. There is evidence that the higher the dose used the more likely it is benzodiazepine use will induce these feelings.
The protracted withdrawal syndrome from benzodiazepines, opioids, alcohol and other addictive substances can produce symptoms identical to generalized anxiety disorder as well as panic disorder. Due to the sometimes prolonged nature and severity of benzodiazepine, opioid and alcohol withdrawal, abrupt cessation is not advised. [13]
Benzodiazepine dependence when it occurs requires withdrawal treatment. There is little evidence of benefit from long-term substitution therapy of benzodiazepines, and conversely, there is growing evidence of the harm of long-term use of benzodiazepines , especially higher doses.
As a generic and the brand names drugs Serax and Zaxopam, oxazepam is used to treat anxiety and certain symptoms of alcohol withdrawal. Other benzodiazepines, such as temazepam and triazolam ...
Seventy-four percent were using Suboxone to ease withdrawal symptoms while sixty-four percent were using it because they couldn’t afford drug treatment. The researchers noted: “Common reasons given for not being currently enrolled in a buprenorphine/naloxone program included cost and unavailability of prescribing physicians.”
Withdrawal symptoms can sometimes resemble pre-existing conditions and be misdiagnosed. Diazepam may produce less intense withdrawal symptoms due to its long elimination half-life. [45] Benzodiazepine treatment is recommended to be discontinued as soon as possible by a slow and gradual dose reduction regimen.
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