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  2. Bacteriophage - Wikipedia

    en.wikipedia.org/wiki/Bacteriophage

    Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.

  3. Luria–Delbrück experiment - Wikipedia

    en.wikipedia.org/wiki/Luria–Delbrück_experiment

    After a period of growth, they plated equal volumes of these separate cultures onto agar containing the T1 phage (virus). If resistance to the virus in bacteria were caused by an induced activation in bacteria i.e. if resistance were not due to heritable genetic components, then each plate should contain roughly the same number of resistant ...

  4. Multidrug-resistant bacteria - Wikipedia

    en.wikipedia.org/wiki/Multidrug-resistant_bacteria

    One major drawback to phage therapy is the evolution of phage-resistant microbes which was seen in a majority of phage therapy experiments aimed to treat sepsis and intestinal infection. [10] Recent studies suggest that development of phage resistance comes as a trade-off for antibiotic resistance and can be used to create antibiotic-sensitive ...

  5. Phage therapy - Wikipedia

    en.wikipedia.org/wiki/Phage_therapy

    Altogether, these mechanisms promote a quick adaptation of bacteria to phage attack and therefore, the emergence of phage-resistant mutants is frequent and unavoidable. [medical citation needed] It is still unclear whether the wide use of phages would cause resistance similar to what has been observed for antibiotics.

  6. Autographiviridae - Wikipedia

    en.wikipedia.org/wiki/Autographiviridae

    “Phage cocktails” are a form of phage therapy that involves employing at least two phages to target a single bacterial strain, [13] creating a form of therapy with greater ‘depth.’ Phage cocktails are an effective substitute for antibiotics as they create a broader host range and delay the development of phage resistance in bacteria. [14]

  7. Restriction modification system - Wikipedia

    en.wikipedia.org/wiki/Restriction_modification...

    The restriction modification system (RM system) is found in bacteria and archaea, and provides a defense against foreign DNA, such as that borne by bacteriophages.. Bacteria have restriction enzymes, also called restriction endonucleases, which cleave double-stranded DNA at specific points into fragments, which are then degraded further by other endonucleases.

  8. Ff phages - Wikipedia

    en.wikipedia.org/wiki/Ff_phages

    Shadowed electron micrograph of unaligned phage. Ff phages (for F specific filamentous phages) is a group of almost identical filamentous phage (genus Inovirus) including phages f1, fd, M13 and ZJ/2, which infect bacteria bearing the F fertility factor.

  9. CrAssphage - Wikipedia

    en.wikipedia.org/wiki/CrAssphage

    The differing responses of B. xylanisolvens indicated that the bacterial population was mixed and consisted of cells both susceptible and resistant to phage infection, similar to the subpopulations of susceptible and resistant hosts in the crAss001 and B. intestinalis phage-host relationship. Similar to crAss001, crAss002 does not possess the ...