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Chlordiazepoxide and diazepam are considered to be among the safer benzodiazepines to use during pregnancy in comparison to other benzodiazepines. Possible adverse effects from benzodiazepine use during pregnancy include, miscarriage, malformation, intrauterine growth retardation, functional deficits, carcinogenesis and mutagenesis.
[81] [102] Less common side effects include nausea and changes in appetite, blurred vision, confusion, euphoria, depersonalization and nightmares. Cases of liver toxicity have been described but are very rare. [24]: 183–189 [106] The long-term effects of benzodiazepine use can include cognitive impairment as well as affective and behavioural ...
Chlordiazepoxide is an anti-anxiety medication belonging to the benzodiazepine class. [4] Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic, [5] a sub-class of a family of drugs known as anticholinergics.
Benzodiazepine Side Effects Benzodiazepines can cause side effects, including some that may affect your alertness, physical health and daily life. Common side effects of benzodiazepines include:
Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the pharmacological effects of a drug will last. Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and ...
Keppra (levetiracetam) – an anticonvulsant drug which is sometimes used as a mood stabilizer and has potential benefits for other psychiatric and neurologic conditions such as Tourette syndrome, anxiety disorder, and Alzheimer's disease; Klonopin – anti-anxiety and anti-epileptic medication of the benzodiazepine class
He thought the compound had a heptoxdiazine structure (Figure 7) but it was later determined to be a quinazoline-3-oxide. Possible drug candidates were then synthesized from that compound and screened for activity. One of these compounds was active, chlordiazepoxide. It was marketed in 1960 and became the first benzodiazepine drug. [30]
Demoxepam [1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide [2] and has anticonvulsant properties [3] [4] and presumably other characteristic benzodiazepine properties.