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  2. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [ 3 ] [ 14 ] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [ 15 ]

  3. Xanomeline/trospium chloride - Wikipedia

    en.wikipedia.org/wiki/Xanomeline/trospium_chloride

    The effectiveness of xanomeline/trospium chloride for the treatment of schizophrenia in adults was evaluated in two studies with identical designs. [2] Study 1 (NCT04659161) and study 2 (NCT04738123) were 5-week, randomized, double-blind, placebo-controlled, multi-center studies in adults with a diagnosis of schizophrenia according to DSM-5 ...

  4. Management of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Management_of_schizophrenia

    The mainstay of treatment for schizophrenia is an antipsychotic medication. [5] Most antipsychotics can take around 7 to 14 days to have their full effect. Medication may improve the positive symptoms of schizophrenia, and social and vocational functioning. [ 6 ]

  5. Atypical antipsychotic - Wikipedia

    en.wikipedia.org/wiki/Atypical_antipsychotic

    The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...

  6. Dopamine antagonist - Wikipedia

    en.wikipedia.org/wiki/Dopamine_antagonist

    Quetiapine binds D 1, D 2 and D 3 and can bind D 4 at high concentrations. [2] It is used to treat the positive symptoms of schizophrenia, [13] bipolar disorder and depression. [1] Of the second generation antipsychotics, quetiapine may produce fewer parkinsonian side effects. [24] Paliperidone binds D 2, D 3 and D 4 with high affinity; can ...

  7. Iloperidone - Wikipedia

    en.wikipedia.org/wiki/Iloperidone

    Iloperidone is indicated for the treatment of schizophrenia and mania or mixed episodes in bipolar I disorder. [2] [3] In a 2013 study in a comparison of 15 antipsychotic drugs in effectivity in treating schizophrenic symptoms, iloperidone demonstrated mild effectiveness -- as effective as lurasidone, and 13 to 15% less effective than ziprasidone, chlorpromazine, and asenapine. [4]

  8. Childhood schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Childhood_schizophrenia

    1 ⁄ 5 of all forms of psychosis of the schizophrenia spectrum; [2] 1.66:1000 among children (0–14 years) [2] Childhood schizophrenia (also known as childhood-onset schizophrenia , and very early-onset schizophrenia ) is similar in characteristics of schizophrenia that develops at a later age, but has an onset before the age of 13 years, and ...

  9. Antipsychotic - Wikipedia

    en.wikipedia.org/wiki/Antipsychotic

    Used for the treatment of schizophrenia and acute mania associated with bipolar disorder. Clozapine (Clozaril) – Of the dibenzodiazepine class of atypical antipsychotics. Requires routine laboratory monitoring of complete blood counts every one to four weeks due to the risk of agranulocytosis. It has unparalleled efficacy in the treatment of ...