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In type I diabetes, IL-13 antagonized cytotoxic insults to pancreatic β cells enhanced by IL-6. [22] In a mouse model of acetaminophen-induced liver injury eosinophil-driven IL-4/IL-13 mediated hepatoprotective function. [23] In severe alcohol-associated hepatitis low plasma level of IL-13 is a predictor of short-term (90-day) mortality. [24]
Activated STAT6 molecules form dimers which translocate to the nucleus to bind responsive elements (e.g. CD23 promoter in B cells, [12] arginase1 enhancer in macrophages [13]) The binding affinity of IL-4 for IL-4Rα is much higher than IL-13 for the IL-13Rα1, hence IL-4 would out-compete IL-13 for receptor availability within IL4R2 at parity ...
Interleukin 13 (IL-13) is a pleiotropic cytokine that may be important in the regulation of the inflammatory and immune responses. [40] It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related. [41]
16164 Ensembl ENSG00000131724 ENSMUSG00000017057 UniProt P78552 O09030 RefSeq (mRNA) NM_001560 NM_133990 RefSeq (protein) NP_001551 NP_598751 Location (UCSC) Chr X: 118.73 – 118.79 Mb Chr X: 35.38 – 35.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. The ...
Pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α also trigger pathological pain. [1] While IL-1β is released by monocytes and macrophages, it is also present in nociceptive DRG neurons. IL-6 plays a role in neuronal reaction to an injury. TNF-α is a well known proinflammatory cytokine present in neurons and the glia.
The Extended Functions module added many functions which had long been requested by users, such as the ability to programmatically assign functions to keys, repartition memory, etc. But the most important new function was the management of extended memory: while the HP-41C could theoretically access up to 1024 registers, the early design ...
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Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene. [ 5 ] Function