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Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis. [1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. [2] The term was coined in 1989. [2]
A Howell–Jolly body (marked by arrow) within an erythrocyte. A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of ...
A – Cabot ring B – Howell-Jolly body Cabot ring Cabot rings are thin, red-violet staining, threadlike strands in the shape of a loop or figure-8 that are found on rare occasions in red blood cells (erythrocytes).
Inclusion bodies have a non-unit (single) lipid membrane [citation needed].Protein inclusion bodies are classically thought to contain misfolded protein.However, this has been contested, as green fluorescent protein will sometimes fluoresce in inclusion bodies, which indicates some resemblance of the native structure and researchers have recovered folded protein from inclusion bodies.
They are a type of inclusion body composed of ferritin aggregates, or mitochondria or phagosomes containing aggregated ferritin. They appear as dense, blue-purple granules within the red blood cell and there are usually only one or two, located in the cell periphery.
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Myeloblast with an Auer rod (to the left of the nucleus).. Auer rods (or Auer bodies) are large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells during acute myeloid leukemia, acute promyelocytic leukemia, high-grade myelodysplastic syndromes and myeloproliferative disorders.