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Dorzolamide was approved for medical use in the United States in 1994. [3] It is available as a generic medication. [5] In 2022, it was the 201st most commonly prescribed medication in the United States, with more than 2 million prescriptions. [6] [7]
Dorzolamide is a sulfonamide and topical carbonic anhydrase II inhibitor. It is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension and who are insufficiently responsive to beta-blockers. Inhibition of carbonic anhydrase II in the ciliary processes of the eye decreases aqueous ...
Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. [ 3 ] [ 5 ] [ 6 ] It is a combination of dorzolamide hydrochloride and timolol maleate. [ 3 ]
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Timolol is a beta blocker medication used either by mouth or as eye drops. [3] [5] As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma. [3]
An off-label prescription is when a healthcare provider prescribes a drug for something it hasn’t been FDA-approved for. Carolina Rudah/Istockphoto. What Are the Benefits of Compounded Tirzepatide?
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.
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