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Agouti is linked to the wideband gene, with about a 30% crossover rate. [33] Like white bellied agouti mice, rabbits with wildtype agouti produce transcripts with different untranslated 5' ends that have different dorsal and ventral expression. The 1A exon is only expressed in the belly region and may be responsible for the lighter color there. [3]
Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. [5] [6] It is responsible for the distribution of melanin pigment in mammals.[7] [8] Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). [9]
Agouti Mice These mice are genetically identical despite looking phenotypically different. The mouse on the left's mother was fed Bisphenol A (BPA) with a normal mouse diet and the mouse on the right's mother was fed BPA with a methyl-rich diet. The left mouse is yellow and obese, while the right mouse is brown and healthy.
The agouti gene in mice is largely responsible for determining coat colour. The wild-type allele produces a blend of yellow and black pigmentation in each hair of the mouse. This yellow and black blend may be referred to as 'agouti' in colour. [3] One of the mutant alleles of the agouti gene
A chimeric mouse gene targeted for the agouti coat color gene, with its offspring. Gene targeting is a biotechnological tool used to change the DNA sequence of an organism (hence it is a form of Genome Editing). It is based on the natural DNA-repair mechanism of Homology Directed Repair (HDR), including Homologous Recombination. Gene targeting ...
The above is an example of the “agouti” gene locus, whereby the insertion of a transposable element upstream to the Agouti gene is hypermethylated from the supplementation and causes a change in the mice's coat color. Diets containing higher carbohydrate and fat content attempt to mimic typical Western-style diets may also be used in ...
In a mice model, the mice fed on a BPA diet were more likely to have a yellow coat corresponding to their lower methylation state in the promoter regions of the retrotransposon upstream of the Agouti gene. The Agouti gene is responsible for determining whether an animal's coat will be banded (agouti) or solid (non-agouti).
11604 Ensembl ENSG00000159723 ENSMUSG00000005705 UniProt O00253 P56473 RefSeq (mRNA) NM_001138 NM_001271806 NM_007427 RefSeq (protein) NP_001129 NP_001258735 NP_031453 Location (UCSC) Chr 16: 67.48 – 67.48 Mb Chr 8: 106.29 – 106.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the ...