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The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Flurazepam [2] (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite with a long half-life, which may stay in the bloodstream for days. [3]
[6] [32] Diazepam is the most commonly used benzodiazepine for "tapering" benzodiazepine dependence due to the drug's comparatively long half-life, allowing for more efficient dose reduction. Benzodiazepines have a relatively low toxicity in overdose. [19] Diazepam has several uses, including:
The elderly metabolize benzodiazepines more slowly than younger people and are also more sensitive to the effects of benzodiazepines, even at similar blood plasma levels. Doses for the elderly are recommended to be about half of that given to younger adults and are to be administered for no longer than two weeks.
Potent benzodiazepines with a relatively short half-life, such as lorazepam, alprazolam, and triazolam, have the highest risk of causing dependence. [ 22 ] If regular treatment is continued for longer than four to six months, dose increases may be necessary to maintain effects, but treatment-resistant symptoms may in fact be benzodiazepine ...
Dederich held that addicts lacked maturity or the ability to handle freedom responsibly. They must be broken down to be built back up. “Comfort is not for adults,” Dederich argued in a taped speech during the commune’s early days. “Comfort destroys adults.” John Peterson was one of the first to move into Synanon, as the commune was ...
The elimination half-life of nitrazepam is 40 hours in the elderly and 29 hours in younger adults. [36] [37] Nitrazepam is commonly taken in overdose by drug abusers or suicidal individuals, sometimes leading to death. [38] [39] [40] Nitrazepam is teratogenic if taken in overdose during pregnancy with 30% of births showing congenital ...
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