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Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt.In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian.
Aspirin causes an increased risk of cerebral microbleeds, having the appearance on MRI scans of 5 to 10 mm or smaller, hypointense (dark holes) patches. [216] [217] A study of a group with a mean dosage of aspirin of 270 mg per day estimated an average absolute risk increase in intracerebral hemorrhage (ICH) of 12 events per 10,000 persons. [218]
The acutely toxic dose of aspirin is generally considered greater than 150 mg per kg of body mass. [12] Moderate toxicity occurs at doses up to 300 mg/kg, severe toxicity occurs between 300 and 500 mg/kg, and a potentially lethal dose is greater than 500 mg/kg. [ 13 ]
Aspirin-modified COX-2 produces 15-epi-lipoxins, which act to resolve inflammatory responses similar to other lipoxins. [7] Newer NSAID drugs called COX-2 selective inhibitors have been developed that inhibit only COX-2, with the hope for reduction of gastrointestinal side-effects. [8]
A review that considered berberine’s effects on heart health found some studies supporting this claim, but due to the high risk of bias, the researchers recommended more clinical trials be ...
Risk of adverse advents such as bleeding or gastrointestinal side effects is relatively high with daily aspirin therapy. Even a 81 mg daily aspirin regimen for cardiovascular benefits has been shown to increase risk of long-term bleeding, [ 27 ] so the significantly higher aspirin doses used for maintenance therapy are of some concern. [ 19 ]
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Sodium bicarbonate can be added to local anaesthetics, to speed up the onset of their effects and make their injection less painful. [49] It is also a component of Moffett's solution, used in nasal surgery. [50] It has been proposed that acidic diets weaken bones. [51] One systematic meta-analysis of the research shows no such effect. [52]