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  2. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    Gabapentin is not a direct calcium channel blocker: it exerts its actions by disrupting the regulatory function of α 2 δ and its interactions with other proteins. Gabapentin reduces delivery of intracellular calcium channels to the cell membrane, reduces the activation of the channels by the α 2 δ subunit, decreases signaling leading to ...

  3. Gabapentin enacarbil - Wikipedia

    en.wikipedia.org/wiki/Gabapentin_enacarbil

    Gabapentin enacarbil (Horizant (ER) (U.S. Tooltip United States), Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. [1] It was designed for increased oral bioavailability over gabapentin, [ 2 ] [ 3 ] and human trials showed it to produce extended release of gabapentin with ...

  4. What is gabapentin? Here's why it's so controversial. - AOL

    www.aol.com/gabapentin-heres-why-controversial...

    Gabapentin is a prescription medication that was approved by the U.S. Food and Drug Administration in 1993 as a treatment for epilepsy. It works by binding to a type of calcium channel in nerve ...

  5. Enalapril - Wikipedia

    en.wikipedia.org/wiki/Enalapril

    Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. [5] For heart failure, it is generally used with a diuretic , such as furosemide . [ 6 ]

  6. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Interactions with other drugs, food and drink, and other factors may increase or decrease the effect of certain analgesics and alter their half-life. Because some listed analgesics are prodrugs or have active metabolites , individual variation in liver enzymes (e.g., CYP2D6 enzyme) may result in significantly altered effects.

  7. Enalaprilat - Wikipedia

    en.wikipedia.org/wiki/Enalaprilat

    Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril. The thiol functional group of captopril was replaced with a carboxylic acid group, but additional modifications were required to achieve a potency similar to captopril.

  8. Analgesic - Wikipedia

    en.wikipedia.org/wiki/Analgesic

    An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...

  9. ACE inhibitor and thiazide combination - Wikipedia

    en.wikipedia.org/wiki/ACE_inhibitor_and_thiazide...

    The FDA modified its labeling in February 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold ( sodium aurothiomalate ) and concomitant ACE inhibitor therapy including Monopril ...

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