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All values in Hematology – red blood cells (except hemoglobin in plasma) All values in Hematology – white blood cells; Platelet count (Plt) A few values are for inside red blood cells only: Vitamin B 9 (folic acid/folate) in red blood cells; Mean corpuscular hemoglobin concentration (MCHC)
A serum folate level of less than 7 nmol/L (3 μg/L) is indicative of folate deficiency; Red blood cell folate testing is not routinely performed, since serum folate is sufficient in most cases, however, if there is a strong suspicion of folate deficiency despite a normal serum folate level, a red cell folate test may be performed.
The 2013–2014 survey reported that for adults ages 20 years and older, men consumed an average of 249 μg/day folate from food plus 207 μg/day of folic acid from consumption of fortified foods, for a combined total of 601 μg/day of dietary folate equivalents (DFEs because each microgram of folic acid counts as 1.7 μg of food folate).
Megaloblastic anemia caused by vitamin B 12 deficiency is characterized by red blood cells that are larger than normal and are unable to deliver oxygen to the body's organs. [7] [8] The clinical case indicates an altered synthesis of DNA, in which vitamin B 12 is essential for the production and maturation of red blood cells in the bone marrow. [8]
Red blood cells have an average volume of 80–100 femtoliters, but individual cell volumes vary even in healthy blood. [1] Certain disorders, however, cause a significantly increased variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5–15.4%.
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Normally, MCV is expressed in femtoliters (fL, or 10 −15 L), and [RBC] in millions per microliter (10 6 / μL). The normal range for MCV is 80–100 fL. If the hematocrit is expressed as a percentage, the red blood cell concentration as millions per microliter, and the MCV in femtoliters, the formula becomes
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