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Collagenous colitis is an inflammatory condition of the colon.Together with the related condition lymphocytic colitis, it is a subtype of microscopic colitis, which is characterized by inflammation that specifically affects the colon (i.e. colitis), and a clinical presentation that involves watery diarrhea but a lack of rectal bleeding.
The previous treatment options had many shortcomings, and the introduction of biological therapy changed the way physicians treat Crohn's disease and ulcerative colitis. [5] [6] Even so, biologic therapy still has its faults such as high cost and risk of side effects.
Standard treatment for ulcerative colitis depends on extent of involvement and disease severity. The goal is to induce remission initially with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important.
Mirikizumab, a drug currently approved by the Food and Drug Administration (FDA) for the treatment of ulcerative colitis, also sends Crohn's disease into clinical remission, new findings suggest.
Vitamin D treatment may be associated with less inflammatory bowel disease reoccurrence of symptoms (relapse). It is not clear if this treatment improves the person's quality of life or what the clinical response to vitamin D treatment. The ideal treatment regime and dose of vitamin D therapy has not been well enough studied. [90]
The prognosis for lymphocytic colitis and collagenous colitis is good, and both conditions are considered to be benign. [10] The majority of people afflicted with the conditions recover from their diarrhea, and their histological abnormalities resolve, [5] although relapses commonly occur if maintenance treatment is not continued. [1] [2]
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NADPH oxidase is an enzyme that effectively reduces O 2 to superoxide (O 2 –•), which can be used by the immune system to kill bacteria and fungi.Apocynin is an inhibitor of NADPH oxidase activity and thus is effective in preventing the production of the superoxide in human agranulocytes or neutrophilic granulocytes.
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