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Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. [ 1 ] It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. [ 1 ]
Esomeprazole, sold under the brand name Nexium [or Neksium] among others, [2] is a medication which reduces stomach acid. [11] It is used to treat gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. [11][12] Its effectiveness is similar to that of other proton pump inhibitors (PPIs). [13]
A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]
October 3, 2023 at 6:59 AM. (Reuters) -Britain's AstraZeneca said it will pay $425 million to settle lawsuits in the United States that claimed its heartburn drugs Nexium and Prilosec caused ...
They include lansoprazole (Prevacid 24 HR), omeprazole (Prilosec) and esomeprazole (Nexium). Long-term use of proton pump inhibitors may increase the risk of bone fracture, kidney disease, or a ...
Proton-pump inhibitor. Proton-pump inhibitors (PPIs) are a class of medications that cause a profound and prolonged reduction of stomach acid production. They do so by irreversibly inhibiting the stomach's H + /K + ATPase proton pump. [1] Proton-pump inhibitors have largely superseded the H 2 -receptor antagonists, a group of medications with ...
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