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Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]
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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The English Wikipedia is the most edited Wikipedia's language version of all time. The English Wikipedia reached 4,000,000 registered user accounts on 1 April 2007, [23] over a year since the millionth Wikipedian registered an account in February 2006. [24] Over 1,100,000 editors have edited Wikipedia more than 10 times. [25]
Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity.
However, phosphodiesterase-5 (PDE5) inhibitors, such as sildenafil (Viagra) and tadalafil (Cialis), are often recommended due to their favorable efficacy and side effect profile and work by increasing the lifespan of the vasodilator nitric oxide in the corpus cavernosum.
The site cross-references the contents of dictionaries such as The American Heritage Dictionary of the English Language, the Collins English Dictionary; encyclopedias such as the Columbia Encyclopedia, the Computer Desktop Encyclopedia, the Hutchinson Encyclopedia (subscription), and Wikipedia; book publishers such as McGraw-Hill, Houghton Mifflin, HarperCollins, as well as the Acronym Finder ...
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
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