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β-Hydroxy β-methylbutyric acid [note 1] (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS.
[1] [2] [3] It is a powdered nutritional supplement that contains 3 grams of calcium β-hydroxy β-methylbutyrate, 14 grams of L-arginine, and 14 grams of L-glutamine per two daily servings. [1] Juven has been shown to increase lean body mass during clinical trials in individuals with AIDS and cancer, but not rheumatoid cachexia.
HMB, or hydroxymethylbutyrate, is being touted online as a muscle building supplement. Dietitians explain what HMB is, its health benefits, and risks. HMB Is Tiktok’s New Muscle Building Supplement.
The US FDA reports 50,000 health problems a year due to dietary supplements [41] and these often involve bodybuilding supplements. [42] For example, the "natural" best-seller Craze, 2012's "New Supplement of the Year" by bodybuilding.com, widely sold in stores such as Walmart and Amazon , was found to contain N,alpha-Diethylphenylethylamine , a ...
FWIW, based upon the prices of currently available HMB-Ca and HMB-FA supplements and the relative efficacy in primary studies between HMB-FA and HMB-Ca, I really doubt MTI is making close to $10,000,000 annually on HMB-FA alone. Seppi 333 (Insert 2¢) 00:51, 17 September 2016 (UTC)
Millions of Americans Might Be Damaging Their Livers Using Herbal Supplements, Study Shows. Korin Miller. August 30, 2024 at 8:00 AM.
However, many of these clinical studies used HMB as a component of combination treatment with glutamine, arginine, leucine, higher dietary protein and/or vitamins, which limits the assessment of the efficacy of HMB alone. [25] [26] Creatine has been shown some promise as a nutritional supplement to treat cachexia, by reducing muscle wasting. [27]
Dr. Pieter Cohen, an associate professor at Harvard Medical School who studies the regulation of supplements, described the proliferation of performance supplements as a “hot mess.”
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