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The replication crisis [a] is an ongoing methodological crisis in which the results of many scientific studies are difficult or impossible to reproduce. Because the reproducibility of empirical results is an essential part of the scientific method , [ 2 ] such failures undermine the credibility of theories building on them and potentially call ...
The project has brought attention to the replication crisis, and has contributed to shifts in scientific culture and publishing practices to address it. [3] The project was led by the Center for Open Science and its co-founder, Brian Nosek, who started the project in November 2011. [4]
The replication fork consists of a group of proteins that influence the activity of DNA replication. In order for the replication fork to stall, the cell must possess a certain number of stalled forks and arrest length. The replication fork is specifically paused due to the stalling of helicase and polymerase activity, which are linked together ...
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Replication (scientific method), one of the main principles of the scientific method, a.k.a. reproducibility Replication (statistics), the repetition of a test or complete experiment; Replication crisis; Self-replication, the process in which an entity (a cell, virus, program, etc.) makes a copy of itself
Origins of replication represent start sites for DNA replication and so their "firing" must be regulated to maintain the correct karyotype of the cell in question. The origins are required to fire only once per cell cycle, an observation that led to the postulated existence of licensing factors by biologists in the first place.
Most of us immediately understand why butter needs to be at room temperature if you intend to cream it with sugar (and remember, you tend to see some iteration of the phrase "beat until fluffy ...
During the replication process, the DNA replication enzymes are not able to copy the ending sequences at the telomere. Those sequences, located at the end of the telomere and chromosome, would hence get lost gradually. Once all of these sequences have been worn out, the useful genetic information in the cell's chromosome would also get lost.