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[67] [68] Taking sertraline only during the luteal phase, that is, the 12–14 days before menses is not as effective as continuous treatment. [66] Continuous treatment with sub-therapeutic doses of sertraline (25 mg vs. usual 50–100 mg) is also effective.
Long-Term Side Effects of Sertraline (Zoloft) Sertraline has been used since the 1990s by tens of millions of people, and in that time there have been no established side effects specific to long ...
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [22]
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Sertraline (Zoloft) As an SSRI antidepressant, escitalopram is commonly prescribed to treat depression. The FDA also approves it for the treatment of generalized anxiety disorder (GAD).
Evidence from 16 clinical trials with a small number of subjects, reviewed in 1994 and 1996 suggested it to be more effective than placebo and as effective as standard antidepressant medication for the treatment of major depression. [134] [needs update]
Despite their side effects, some tricyclic antidepressants may be effective for improving depression symptoms when other, newer medications aren’t effective. Atypical antidepressants.
Fluoxetine also has a long half-life which can reduce withdrawal symptoms which are characteristic for some SSRIs after abrupt discontinuation, but it also means that it takes a long time to clear the drug and its active metabolite after discontinuing fluoxetine treatment. [18] Figure 5 Chemical structure of (–)-(3S,4R)-paroxetine