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The extracts of Chasteberry Vitex agnus castus improve premenstrual symptoms, especially premenstrual mastodynis (breast pain) which is caused by hyperprolactinemia and hence explains female infertility. In addition, low progesterone level is also attributed to female infertility.
Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
[49] [28] [50] [51] Periovulatory levels of estradiol increase sexual desire in postmenopausal women. [49] Based on animal research, progesterone may also be involved in sexual function in women. [52] [53] [54] Very limited clinical research suggests that progesterone does not increase sexual desire and may decrease it. [55]
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Vitex agnus-castus (also called vitex, chaste tree / chastetree, chasteberry, Abraham's balm, [1] lilac chastetree, [2] or monk's pepper) is a plant native of the Mediterranean region. It is one of the few temperate-zone species of Vitex , which is on the whole a genus of tropical and subtropical flowering plants . [ 3 ]
[84] [85] [86] The preceding side effects of synthetic estrogens do not appear to occur in pregnant women, who already have very high estrogen levels. [84] This suggests that these effects are due to estrogenic activity. [84] Synthetic estrogens have markedly stronger effects on the liver and hepatic protein synthesis than natural estrogens.
[9] [10] Moreover, a trial of hormonal breast enhancement in 45 young women with very high doses (80 mg/injection) of intramuscular, bioidentical estrogen (in the form of estradiol polyphosphate, a slow-releasing estradiol prodrug) for six months found that only the women in whom an increase in IGF-1 levels occurred after four weeks (46.7% of ...
In addition, whereas bicalutamide monotherapy can increase testosterone levels by up to 2-fold in men, [64] [76] the medication does not increase testosterone levels in women. [ 77 ] [ 78 ] [ 79 ] For these reasons, much lower dosages of bicalutamide (e.g., 25 mg/day in the hirsutism studies) may be used in women with significant antiandrogenic ...