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Subacute compression develops over days to weeks. Acute compression develops within minutes to hours. Acute compression may follow subacute and chronic compression, especially if the cause is abscess or tumor. Regardless of the pace, spinal cord compression will predictably progress over time. [1] [2]
2011 Review Article: Cancer Pain Management in Resource-Limited Settings: A Practice Review [16] 2011 Palliative care making a difference in rural Uganda, Kenya and Malawi: three rapid evaluation field studies [6] 2008 Interventions for the treatment of metastatic extradural spinal cord compression in adults [17]
In advanced stages of prostate cancer, radiation is used to treat painful bone metastases or reduce spinal cord compression. Radiation therapy is also used after radical prostatectomy either for cancer recurrence or if multiple risk factors are found during surgery.
Bone metastases can cause severe pain, bone fractures, spinal cord compression, hypercalcemia, anemia, spinal instability, decreased mobility, and rapid degradation in the quality of life for patients. [7] [8] Patients have described the pain as a dull ache that grows worse over time, with intermittent periods of sharp, jagged pain. [3]
The spinal cord is a long, cylindrical anatomical structure that is located within the vertebral cavity. It runs from the foramen magnum of the skull to the conus medullaris at the lumbar spine. [1] Most symptoms from spinal tumors occur due to compression of the spinal cord as it plays a primary role in motor and sensory function. [13]
Compression of the long tracts of the cord itself produces funicular pain and compression of a spinal nerve root produces radicular pain. Seventy percent of cases involve the thoracic, 20 percent the lumbar, and 10 percent the cervical spine; and about 20 percent of cases involve multiple sites of compression. The nature of the pain depends on ...
A compression fracture is a collapse of a vertebra. It may be due to trauma or due to a weakening of the vertebra (compare with burst fracture ). This weakening is seen in patients with osteoporosis or osteogenesis imperfecta , lytic lesions from metastatic or primary tumors , [ 1 ] or infection. [ 2 ]
This contributes to narrowing the spinal canal and compressing the spinal cord in the corresponding region. Herniated disk due to tearing of the spinal disk over time, causes the disk to protrude and exert pressure on surrounding spinal nerve tissue. Consequent compression on the spinal cord at the cervical region causes CSM. [12]
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