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Sadun has focused his research on diseases of the optic nerve, ... A Board-Review Manual ... Clearing the cornea with nerve growth factor. New England Journal of ...
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor , in that it was one of the first to be described.
The arrival of the nerve induces clustering of the receptors at the synapse. McMahan and Sanes showed that the synaptogenic signal is concentrated at the basal lamina. They also showed that the synaptogenic signal is produced by the nerve, and they identified the factor as Agrin. Agrin induces clustering of AchRs on the muscle surface and ...
New research links Ozempic to a rare side effect that may affect eye health. Design by MNT; Photography by Community Eye Health, CC BY-NC 2.0 & NurPhoto/Getty Images
The PAX6 gene locus is a transcription factor for the various genes and growth factors involved in eye formation. [1] [5] Eye morphogenesis begins with the evagination, or outgrowth, of the optic grooves or sulci.
Pathologically, Pax2 has been demonstrated to activate hepatocyte growth factor (HGF) gene promoter, and both have been indicated as playing a role in human prostate cancers. [11] Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript ...
Secondary glaucoma is a collection of progressive optic nerve disorders associated with a rise in intraocular pressure (IOP) which results in the loss of vision. In clinical settings, it is defined as the occurrence of IOP above 21 mmHg requiring the prescription of IOP-managing drugs. [ 1 ]
In healthy nerves, nerve growth factor (NGF) is produced in very small amounts. However, upon injury, NGF mRNA expression increases by five to seven-fold within a period of 14 days. Nerve fibroblasts and Schwann cells play an important role in increased expression of NGF mRNA. [25]
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