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Oncomodulin is highly conserved across vertebrate evolution (NCBI database). It is a smaller calcium-binding protein (11.7-kDa) which resembles the EF-hand domain of calmodulin (32% sequence identity), alpha-parvalbumin (54%), S100-beta (34%), and calbindin (25%) and resembles alpha-parvalbumin in its N-terminal region (52%).
4803 18049 Ensembl ENSG00000134259 ENSMUSG00000027859 UniProt P01138 P01139 RefSeq (mRNA) NM_002506 NM_001112698 NM_013609 RefSeq (protein) NP_002497 NP_001106168 NP_038637 Location (UCSC) Chr 1: 115.29 – 115.34 Mb Chr 3: 102.38 – 102.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the ...
Sadun has focused his research on diseases of the optic nerve, ... Clearing the cornea with nerve growth factor. New England Journal of Medicine, 338(17), 1222–1223.
The PAX6 gene locus is a transcription factor for the various genes and growth factors involved in eye formation. [1] [5] Eye morphogenesis begins with the evagination, or outgrowth, of the optic grooves or sulci.
In healthy nerves, nerve growth factor (NGF) is produced in very small amounts. However, upon injury, NGF mRNA expression increases by five to seven-fold within a period of 14 days. Nerve fibroblasts and Schwann cells play an important role in increased expression of NGF mRNA. [25]
It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver. This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily.
In follow-up experiments, the eye was detached and rotated 180° like before, but additionally the optic nerve was cut—the results were identical. [ citation needed ] Sperry hypothesized that each individual optic nerve and tectal neuron used some form of chemical marker to dictate the connectivity during development.
Pathologically, Pax2 has been demonstrated to activate hepatocyte growth factor (HGF) gene promoter, and both have been indicated as playing a role in human prostate cancers. [11] Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript ...
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