Search results
Results from the WOW.Com Content Network
The term "click chemistry" was coined in 1998 by Sharpless' wife, Jan Dueser, [3] who found the simplicity of this approach to chemical synthesis akin to clicking together Lego blocks. In fact, the simplicity of click chemistry represented a paradigm shift in synthetic chemistry, and has had significant impact in many industries, especially ...
The term "click chemistry" was coined by Sharpless around the year 2000, and was first fully described by Sharpless, Hartmuth Kolb, and M.G. Finn at The Scripps Research Institute in 2001. [ 11 ] [ 2 ] This involves a set of highly selective, exothermic reactions which occur under mild conditions; the most successful example is the azide alkyne ...
American chemist Karl Barry Sharpless has referred to copper-catalyzed version of this cycloaddition as "the cream of the crop" of click chemistry [2] and "the premier example of a click reaction". [3] Thermal Huisgen 1,3-dipolar cycloaddition.
[1] [5] The associated scientific publication Click chemistry: diverse chemical function from a few good reactions has been cited more than 14,000 times (as of 2021) and was the foundation for the 2022 Nobel Prize in Chemistry for K. Barry Sharpless, Carolyn Bertozzi and Morten Meldal. [6]
In developing small molecule drugs for its validated targets, Lexicon uses medicinal chemistry known as "click chemistry." Dr. K. Barry Sharpless, who was awarded the 2001 Nobel Prize in Chemistry, [11] pioneered this set of powerful and reliable tools for the rapid synthesis of novel compounds. Lexicon uses solution-phase chemistry to generate ...
Barry Sharpless was the first to develop a general, reliable enantioselective alkene dihydroxylation, referred to as the Sharpless asymmetric dihydroxylation (SAD). Low levels of OsO 4 are combined with a stoichiometric ferricyanide oxidant in the presence of chiral nitrogenous ligands to create an asymmetric environment around the oxidant.
The Sharpless epoxidation, developed by K. Barry Sharpless in 1980, [14] has been utilized for the kinetic resolution of a racemic mixture of allylic alcohols. [15] [16] While extremely effective at resolving a number of allylic alcohols, this method has a number of drawbacks. Reaction times can run as long as 6 days, and the catalyst is not ...
The Sharpless epoxidation is viable with a large range of primary and secondary alkenic alcohols. Furthermore, with the exception noted above, a given dialkyl tartrate will preferentially add to the same face independent of the substitution on the alkene.To demonstrate the synthetic utility of the Sharpless epoxidation, the Sharpless group created synthetic intermediates of various natural ...