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A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. [1] Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive immunity), [2] [3] and innate lymphoid cells (ILCs; "innate T cell-like" cells involved in mucosal immunity and homeostasis), of which natural killer cells are an ...
The Jurkat cell line (originally called JM) was established in the mid-1970s from the peripheral blood of a 14-year-old boy with T cell leukemia. [2] [3] Different derivatives of the Jurkat cell line that have been mutated to lack certain genes can now be obtained from cell culture banks.
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Lymphocytes are distinguished by having a deeply staining nucleus that may be eccentric in location, and a relatively small amount of cytoplasm. Lymphocytes include: B cells make antibodies that can bind to pathogens , block pathogen invasion, activate the complement system , and enhance pathogen destruction.
Lymphocytes generate the immune repertoire by recombining the genes encoding immunoglobulins and T cell receptors through V(D)J recombination.Although there are only a few of these genes, all their possible combinations can result in a wide variety of immune repertoire proteins.
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Lymphocytic esophagitis is a rare and poorly understood medical disorder involving inflammation in the esophagus.The disease is named from the primary inflammatory process, wherein lymphocytes are seen within the esophageal mucosa.