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Serotonin is a neurotransmitter involved in multiple complex biological processes including aggression, pain, sleep, appetite, anxiety, depression, migraine, and vomiting. [10] In humans the effects of excess serotonin were first noted in 1960 in patients receiving an MAOI and tryptophan. [54] The syndrome is caused by increased serotonin in ...
Research suggests that individuals with late life depression are more likely to develop Alzheimer's Disease, vascular dementia, and all-cause dementia. Dementia, however, can present early in its disease course with depressive symptoms, meaning that this association could actually be reflecting that dementia causes late life depression. [ 23 ]
Currently, the treatment of pseudodementia is mainly focused on treating depression, cognitive impairment, and dementia. And we have seen improvements in cognitive dysfunction with antidepressants such as SSRI (Selective serotonin Reuptake Inhibitors), SNRI (Serotonin-norepinephrine Reuptake Inhibitors), TCAs (Tricyclic Antidepressants ...
It does this by concomitantly inhibiting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), respectively. Inhibition of the reuptake of these neurotransmitters increases their extracellular concentrations and, therefore, results in an increase in serotonergic, adrenergic, and dopaminergic ...
Dementia and brain disorders are getting a lot of attention these days. And for good reason. About 1 in 10 Americans over 65 have dementia. And it’s estimated that the number of people 65 and ...
Selective serotonin reuptake inhibitors (SSRIs) selectively inhibit the reuptake of serotonin and are a widely used group of antidepressants. [31] With increased receptor selectivity compared to TCAs, undesired effects such as poor tolerability are avoided. [29] Serotonin is synthesized from an amino acid called L-tryptophan.
Atypical depression also often features significant weight gain or an increased appetite, hypersomnia, a heavy sensation in the limbs, and interpersonal rejection sensitivity that results in significant social or occupational impairment. [4] Despite its name, "atypical" depression does not mean it is uncommon or unusual. [5]
Patients on the blood-thinning drug Warfarin experienced higher rates of dementia and Alzheimer's, according to a new study. Widely-used heart drug linked to increased dementia risk Skip to main ...