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The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3]
Acrogeria (Gottron's syndrome) is a skin condition characterized by premature aging, typically in the form of unusually fragile, thin skin on the hands and feet (distal extremities). [ 1 ] This is one of the classic congenital premature aging syndromes, occurring early in life, others being pangeria ( Werner's syndrome ) and progeria ...
Fissure is a lesion in the skin that is usually narrow but deep. [29] [33] Induration is dermal thickening causing the cutaneous surface to feel thicker and firmer. [29] Atrophy refers to a loss of skin, and can be epidermal, dermal, or subcutaneous. [30] With epidermal atrophy, the skin appears thin, translucent, and wrinkled. [29]
Skin fragility syndrome (also known as "plakophilin 1 deficiency") is a cutaneous condition characterized by trauma-induced blisters and erosions. [ 1 ] It is associated with PKP1 .
Other skin symptoms include molluscoid pseudotumors, [59] especially on pressure points, petechiae, [60] subcutaneous spheroids, [59] livedo reticularis; piezogenic papules are less common. [61] In vascular EDS, skin can also be thin and translucent. In dermatosparaxis EDS, the skin is extremely fragile and saggy. [1]
Later, the condition causes wrinkled skin, kidney failure, loss of eyesight, and atherosclerosis and other cardiovascular problems. [12] Scleroderma, a hardening and tightening of the skin on trunk and extremities of the body, is prevalent. People diagnosed with this disorder usually have small, fragile bodies, like those of older adults.
Skin fragility-woolly hair-palmoplantar keratoderma syndrome is a very rare genetic disorder which is characterized by fragile skin which shows itself as blisters and erosion due to trauma that wouldn't typically cause those type of lesions, woolly hair with alopecia, nail dysplasia, widespread or local palmoplantar keratoderma associated with painful fissuring.
Poikiloderma vasculare atrophicans (PVA), is a cutaneous condition (skin disease) characterized by hypo- or hyperpigmentation (diminished or heightened skin pigmentation, respectively), telangiectasia and skin atrophy. [3] [4] [5] Other names for the condition include prereticulotic poikiloderma and atrophic parapsoriasis. [6]
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