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Vaginal estrogen, which includes creams, pills, rings, and inserts, is more commonly prescribed due to its lower risk. DHEA (prasterone) is a promising alternative that enhances vaginal health with minimal side effects and does not significantly alter hormone levels. [8]
Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA. [20] DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS). [54] [55] The terminal half-life of DHEA is short at only 15 to 30 minutes. [56] In contrast, the terminal half-life of DHEA-S is far longer, at 7 to 10 hours. [56]
The vagina is an important part of the female anatomy, but many people know very little about it. "When we do exams in the office, we get out a mirror, show women their vaginas and point out the ...
Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for ...
Penile–vaginal intercourse, or vaginal intercourse, is a form of penetrative sexual intercourse in human sexuality, in which an erect penis is inserted into a vagina. [1] Synonyms are: vaginal sex , cohabitation , coitus ( Latin: coitus per vaginam ), (in elegant colloquial language) intimacy , or (poetic) lovemaking .
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration ...
Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. [1] It is the 3β- sulfate ester and a metabolite of dehydroepiandrosterone (DHEA) and circulates in far greater relative concentrations than DHEA. [ 2 ]
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