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The protein may also exhibit a "gain of function" or become activated, such is the case with the mutation changing a valine to glutamic acid in the BRAF gene; this leads to an activation of the RAF protein which causes unlimited proliferative signalling in cancer cells. [5] These are both examples of a non-conservative (missense) mutation.
[56] [57] Another research frontier is the analysis of single cells, [74] [75] and protein covariation across single cells [76] which reflects biological processes such as protein complex formation, immune functions, [77] as well as cell cycle and priming of cancer cells for drug resistance [78] Biological systems are subject to a variety of ...
Protein function is a broad term: the roles of proteins range from catalysis of biochemical reactions to transport to signal transduction, and a single protein may play a role in multiple processes or cellular pathways. [1] Generally, function can be thought of as, "anything that happens to or through a protein". [1]
Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. [1] [2] All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of organisms. [3] Cell biology is the study of the structural and functional ...
However, the proposed connection between a single gene and a single protein enzyme outlived the protein theory of gene structure. In a 1948 paper, Norman Horowitz named the concept the "one gene–one enzyme hypothesis". [2] Although influential, the one gene–one enzyme hypothesis was not unchallenged.
Protein–protein interactions regulate enzymatic activity, control progression through the cell cycle, and allow the assembly of large protein complexes that carry out many closely related reactions with a common biological function. Proteins can bind to, or be integrated into, cell membranes.
Every cell consists of cytoplasm enclosed within a membrane; many cells contain organelles, each with a specific function. The term comes from the Latin word cellula meaning 'small room'. Most cells are only visible under a microscope. Cells emerged on Earth about 4 billion years ago. All cells are capable of replication, protein synthesis, and ...
Biology is the scientific study of life. [1] [2] [3] It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. [1] [2] [3] For instance, all organisms are composed of at least one cell that processes hereditary information encoded in genes, which can be transmitted to future ...