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  2. Rubicon (protein) - Wikipedia

    en.wikipedia.org/wiki/Rubicon_(protein)

    Rubicon (run domain Beclin-1-interacting and cysteine-rich domain-containing protein) is a protein that in humans is encoded by the RUBCN gene. [5] [6] Rubicon is one of the few known negative regulators of autophagy, a cellular process that degrades unnecessary or damaged cellular components. [7]

  3. Fatty liver disease - Wikipedia

    en.wikipedia.org/wiki/Fatty_liver_disease

    Fatty liver (FL) is commonly associated with metabolic syndrome (diabetes, hypertension, obesity, and dyslipidemia), but can also be due to any one of many causes: [14] [15] Alcohol Alcohol use disorder is one of the causes of fatty liver due to production of toxic metabolites like aldehydes during metabolism of alcohol in the liver. This ...

  4. Chaperone-mediated autophagy - Wikipedia

    en.wikipedia.org/wiki/Chaperone-mediated_autophagy

    The ability of CMA to selectively degrade enzymes involved in the metabolism of free fatty acids (i.e. linoleic and linolic pathway) has proven key for activation of hematopoietic stem cells, [16] thus supporting a role for CMA in stem cell function. CMA activity is upregulated during differentiation of embryonic stem cells and contributed to ...

  5. Autophagy - Wikipedia

    en.wikipedia.org/wiki/Autophagy

    A Diagram of the process of autophagy, which produces the structures autophagosomes (AP), and autolysosomes (AL); B Electron micrograph of autophagic structures AP and AL in the fat body of a fruit fly larva; C Fluorescently-labeled autophagosomes AP in liver cells of starved mice. Autophagy (or autophagocytosis; from the Greek ...

  6. Eli Lilly Seeks To Expand Into Cancer Radiopharma And Fatty ...

    www.aol.com/eli-lilly-seeks-expand-cancer...

    Eli Lilly Seeks To Expand Into Cancer Radiopharma And Fatty Liver, With Two Global Deals. Vandana Singh. February 10, 2025 at 10:55 AM.

  7. Starvation response - Wikipedia

    en.wikipedia.org/wiki/Starvation_response

    Starvation response in animals (including humans) is a set of adaptive biochemical and physiological changes, triggered by lack of food or extreme weight loss, in which the body seeks to conserve energy by reducing metabolic rate and/or non-resting energy expenditure to prolong survival and preserve body fat and lean mass.

  8. Metabolic dysfunction–associated steatotic liver disease

    en.wikipedia.org/wiki/Metabolic_dysfunction...

    Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), [a] is a type of chronic liver disease. This condition is diagnosed when there is excessive fat build-up in the liver ( hepatic steatosis ), and at least one metabolic risk factor.

  9. Liver disease - Wikipedia

    en.wikipedia.org/wiki/Liver_disease

    Non-alcoholic fatty liver disease is a spectrum of disease associated with obesity and metabolic syndrome. [9] Hereditary diseases that cause damage to the liver include hemochromatosis, [10] involving accumulation of iron in the body, and Wilson's disease. Liver damage is also a clinical feature of alpha 1-antitrypsin deficiency [11] and ...

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