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In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
The MSTN gene provides instructions for making a protein called myostatin, which is active in muscles used for movement (skeletal muscles) both before and after birth. A 2010 research paper in the Journal of Musculoskeletal & Neuronal Interactions, which was discussed outside of academic circles, [ 3 ] linked Myostatin to muscle mass and bone ...
Myostatin inhibitors are a class of drugs that work by blocking the effect of myostatin, which inhibits muscle growth.In animal models and limited human studies, myostatin inhibitors have increased muscle size.
The MSTN gene also plays a big role in muscle development. It provides instructions for making a protein called myostatin. This protein transforming growth factor beta (TGFβ) superfamily, which is a group of proteins that help control the growth and development of tissues throughout the body.
Biochemical studies showed a phosphorylase activity just below normal range, with other activities being normal. Southern blot analysis revealed a deletion of exons 45 to 48 of dystrophin gene, which on Western blotting was shown to produce normal amounts of truncated dystrophin. [74] Hereditary myopathy with lactic acidosis (HML) (gene ISCU)
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15235 Ensembl ENSG00000173531 ENSMUSG00000032591 UniProt P26927 P26928 RefSeq (mRNA) NM_020998 NM_001393581 NM_001393582 NM_001393583 NM_001393584 NM_001393585 NM_008243 RefSeq (protein) NP_066278 NP_032269 Location (UCSC) Chr 3: 49.68 – 49.69 Mb Chr 9: 107.96 – 107.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Macrophage-stimulating protein (MSP), also known as hepatocyte ...
Dr Emmeline Hill is an Irish horse geneticist who is credited with discovering a gene for speed in horses.. Dr Hill has published a paper in the peer-reviewed scientific journal PLoS ONE entitled "A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in Thoroughbred horses", which describes the identification of the DNA sequence variant in the horse myostatin gene.